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Coversyl 8 | (Perindopril Arginine)| Class: ACE Inhibitor | Manufacturer: Servier Bangladesh Operation (Mfg. by Eskayef Pharmaceuticals Ltd.)
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✅ Description:
Coversyl 8 is prescribed for the effective management of:
- High blood pressure (Hypertension) – to reduce elevated blood pressure and associated symptoms such as morning headaches, fatigue, irregular heartbeat, and chest discomfort.
- Heart failure – to improve cardiac efficiency and relieve symptoms like breathlessness and rapid heartbeat.
- Prevention of major cardiovascular events, particularly in patients with stable coronary artery disease, including those with a prior heart attack or coronary revascularization surgery.
Not recommended in patients with bilateral renal artery stenosis.
Use with caution in patients with:
- Aortic stenosis
- Hypertrophic cardiomyopathy
- Chronic kidney or liver disease
- Diabetes mellitus
- Undergoing dialysis
Pregnancy & Breastfeeding: Not advised unless clearly necessary; consult a healthcare professional.
Pediatric Use: Not recommended for individuals under 18 years of age.
Routine checks of kidney function, serum electrolytes (especially potassium), and blood pressure are essential during treatment.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Mechanism of Action
Perindopril works by inhibiting the angiotensin-converting enzyme (ACE), which normally narrows blood vessels. By blocking this enzyme, COVERSYL promotes vasodilation (widening of blood vessels), improving blood flow and reducing blood pressure, which ultimately lowers the workload on the heart.
✔️ Common Side Effects of Coversyl 8
- Dizziness or light-headedness (especially after first doses)
- Headache
- Cough (persistent and dry)
- Muscle cramps
- Hypotension (low blood pressure)
- Breathlessness or fatigue
Seek medical advice if any side effects persist or worsen.
✔️ Overdose Management of Coversyl 8
Signs of overdose:
Profound hypotension, dizziness, fainting, and circulatory shock.
Action:
Seek immediate medical attention or visit the nearest hospital if an overdose is suspected.
✔️ Dosage & Administration of Coversyl 8
Hypertension:
The recommended starting dose is Perindopril 4 mg once daily, preferably in the morning. If blood pressure remains uncontrolled, the dose may be increased to 8 mg once daily after at least 1 month, based on clinical response and tolerance. Administer before meals.
Stable Coronary Artery Disease:
Begin with 4 mg once daily for 2 weeks, then titrate to 8 mg once daily if well tolerated and renal function is adequate.
In elderly patients, start with 2 mg once daily for 1 week, followed by 4 mg for another week, then increase to 8 mg only if the previous dose was well tolerated.
Congestive Heart Failure:
Initiate with 2 mg once daily, preferably under close medical supervision. If necessary, increase to 4 mg daily depending on clinical response.
Elderly Patients:
Start with lower doses (4 mg or less) and adjust gradually. Limited experience exists with doses above 8 mg in older populations.
✔️ Inform your doctor if you are using any of the following medications, as they may interact with perindopril:
Other antihypertensives:
- ARBs (e.g., losartan, valsartan)
- Aliskiren (avoid combination in diabetic or renal-impaired patients)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Potassium-elevating drugs:
- Salt substitutes with potassium
- Potassium-sparing diuretics (e.g., spironolactone, amiloride)
Antibiotics:
- Trimethoprim (increased risk of hyperkalemia)
- Immunosuppressants:
- Ciclosporin, tacrolimus
- Blood thinners:
- Heparin
NSAIDs:
- Aspirin, ibuprofen (may blunt antihypertensive effects and impair renal function)
Others:
- Baclofen (increased risk of hypotension)
- Lithium (risk of lithium toxicity)
- Antidepressants (e.g., citalopram, paroxetine)
- Estramustine (increased risk of adverse effects)
- Procainamide (risk of heart rhythm disturbances)
- Sympathomimetics (e.g., adrenaline, noradrenaline may counteract perindopril.
- Vasodilators (e.g., nitroglycerine, isosorbide)
- Antidiabetics (e.g., insulin, metformin) may increase the risk of hypoglycemia.
- Allopurinol (increased hypersensitivity risk)
- Gold salts (may cause nitrosoaniline reactions)
- mTOR inhibitors (e.g., sirolimus, everolimus – potential for angioedema)
✔️ Inform your physician before taking Coversyl 8 if you have:
- Primary aldosteronism
- Connective tissue disorders (e.g., lupus, scleroderma)
- Recent major surgery, anesthesia, or LDL apheresis
- Scheduled allergy desensitization therapy
- History of dehydration, vomiting, or diarrhea
- Conditions like diabetes, salt-restricted diets, or sugar intolerance
- Use of potassium supplements or salt substitutes
- Liver or kidney impairment, including patients on dialysis
✔️ Storage:
- Keep Coversyl 8 out of reach of children
- Store at room temperature
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
